I've been getting into mathematical models lately, and have noticed
that many of these models don't really take into account the signaling
complexities of biology. To this end I was wondering if anyone could
point me in the direction of a general equation, etc. that models
either the process of selecting a gene to be transcribed in a cell
(all of the different transcription affinity and negating factors), or
of quantifying the amount of mobilization of an enzyme which is
activated through a complex enzyme cascade. A name of an equation or
modeling style would be enough to get me started, I haven't been able
to find much of anything beyond the idea of the stochastic general
equation and markov, non-markov type equations. To put a context to
this broad question, I'm interested in the ligand gated g protein
receptor cascades in neurons, and the control of receptor populations/
synapse modulation (synaptic placticity) at a genetic (or at any
other) level. Having looked over a goodly amount of articles it seems
to me like this has been mainly studied at a qualitative level, much
less so at a specific quantitative level. Sorry to pollute the board
with my neuroscience again :P, but I think this would be interesting
to the slightly higher level genetics researchers here as well. :)
Thanks for any information in advance, and I apologize for my
ignorance if this is a commonly understood topic, I don't really have
access to a professor of, well, anything. :)
Jonathan Nesser
diybioandneurosci.blogspot.com
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