There are several assays used for telomere length determination. Originally, DNA would be cut with a restriction enzyme that cuts in from the telomere repeat (in the subtelomeric region, I think), run on an agarose gel, and then Southern blotted and probed with telomere repeat sequence or a subtelomeric probe.
-- Then telomere PCR was developed which would generate a ladder of bands, one for each repeat. Variants on this and qPCR based methods have also been developed.
A method using ordinary PCR would be the easiest to implement as a DIY project.
Here is a review:
And more reviews: http://www.ncbi.nlm.nih.gov/pubmed?cmd=link&linkname=pubmed_pubmed_reviews&uid=21663926&log$=relatedreviews&logdbfrom=pmc
Jim Lund
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