[DIYbio] DIY gene therapy for epigenome reset

Hello guys,

So there is a lab that was able to obtain amazing rejuvenation effects on mouse using an AAV (AFAIK) gene therapy to deliver 3 genes (Oct4, Klf4, Sox2), with a promoter activated by doxycycline. I was wondering if any of you was by chance working on it? If not, I'd love to get my hand dirty and try it on my own mouses (for real, this needs like lot more safety test).

Any suggestions about this? Any pointer to get started for a beginner with a very high level only knowledge of bio and genetics?

Thanks
Raph

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