Re: [DIYbio] Re: embed colloid in temperature controlled system --> release phage into human gut (adds heat and pH); releases gene therapy.

Hi Dan, thank you for the response.

Since I posted about colloids I have been driving down on something I am more comfortable with, namely engineered gram + bacterial circuits to express the antibodies. If I picked the right species in terms of cell envelope properties, this might engender a "time release" which would allow the engineered bacteria to escape the infernal alimentary canal and enter the bloodstream, at which point they might release the antibodies and establish a titer. 

(As you can see I am jumping over hoops to avoid injection, and that is the point - I am trying to provide an alternative medical experience for those who are worried about conspiracies or antivaxx or whatever.) There are some oral vaccine projects in play e.g. for polio and even some in development for covid, but then these are pharmaceutical interventions and at the end of the day I am trying to promote a medical atmosphere that has very little to do with medicine in its trappings (antiviral coffee) but still produces an ameliorative health outcome.

All the best,

Aaron

On Sat, Jul 8, 2023 at 10:54 AM Dan Kolis <dankolis@gmail.com> wrote:

Hmmm, well that esophagus, stomach stuffola ; ( AKA alimentary canal ) , does a lot of stuff, there's some acid in there, lots of enzymes .. it goes in both directions if things go badly...

BUT ! I think it also normalises temperature, in like tens of seconds after a 'trip south' gulp.

A "lots of gaps', yes including thermodynamics.

A tough project: "To swallow"; yet GOOD LUCK and don't drink too much N2 !

Regs,
Dan



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