Re: [DIYbio] Pathogenic Mosquito Sanitizer?

Of course, this is all getting pretty complicated. It would probably be better to focus both on reinforcing a population mosquitoes with an aversion to human hosts (through natural breeding, perhaps, or maybe through a virus that targets the chromosomes of undeveloped larvae directly), and on breeding predators/parasites/non-lethal competing strains of Plasmodium.

On Saturday, June 2, 2012 4:07:58 PM UTC-4, Matthias wrote:t

mechanism, by which your engineered bacteria profit
from poisoning disease causing bacteria.
So after a while they will loose this ability,
as well as the diseases becoming resistent.
By "cleaning" the mosquitos they create a habitat,
which will be re-invaded after some time.
What would be the mechanism of spread for your bacteria?
What mosquito-bacteria symbiosis relationships would
you disrupt, thereby motivating the mosquitos to
get rid of your bacteria?
The mosquitos would then also transfer low amounts of
your antibiotic onto the hosts they feed from,
thereby forcing the development of resistant bacteria
in the host as well as in the mosquito.
If all this is answeared, you still have the technical
question how to develop a pathogen that selectively
infects disease spreading mosquitos, inable to mutate
to infect other species, and being biochemically able
to invade and life inside a mosquito, being transfered
from mosquito to mosquito.

Cheers, Matthias


Am Samstag, den 02.06.2012, 01:12 -0700 schrieb Margret Storm:
> Would it be possible to engineer a contagious bacterial strain that
> resided in the digestive tracts of mosquitoes, and had little effect
> other than releasing antimicrobial enzymes into the pharynx and
> salivary glands? Hopefully, this would prevent the spread of
> mosquito-borne diseases like malaria, as well as help prevent
> secondary infection of bites.
>
>
> Forgive me in advance for any ignorance - the idea has been bugging me
> (hah), and I really want to know.

On Saturday, June 2, 2012 4:07:58 PM UTC-4, Matthias wrote:

Sounds like a big undertaking, with all these details
you want to have done at the same time.
And it sounds quite "forced".
Technically it is possible of course, but
the investment would be huge and won't pay off, since there is no
mechanism, by which your engineered bacteria profit
from poisoning disease causing bacteria.
So after a while they will loose this ability,
as well as the diseases becoming resistent.
By "cleaning" the mosquitos they create a habitat,
which will be re-invaded after some time.
What would be the mechanism of spread for your bacteria?
What mosquito-bacteria symbiosis relationships would
you disrupt, thereby motivating the mosquitos to
get rid of your bacteria?
The mosquitos would then also transfer low amounts of
your antibiotic onto the hosts they feed from,
thereby forcing the development of resistant bacteria
in the host as well as in the mosquito.
If all this is answeared, you still have the technical
question how to develop a pathogen that selectively
infects disease spreading mosquitos, inable to mutate
to infect other species, and being biochemically able
to invade and life inside a mosquito, being transfered
from mosquito to mosquito.

Cheers, Matthias


Am Samstag, den 02.06.2012, 01:12 -0700 schrieb Margret Storm:
> Would it be possible to engineer a contagious bacterial strain that
> resided in the digestive tracts of mosquitoes, and had little effect
> other than releasing antimicrobial enzymes into the pharynx and
> salivary glands? Hopefully, this would prevent the spread of
> mosquito-borne diseases like malaria, as well as help prevent
> secondary infection of bites.
>
>
> Forgive me in advance for any ignorance - the idea has been bugging me
> (hah), and I really want to know.

On Saturday, June 2, 2012 4:07:58 PM UTC-4, Matthias wrote:

Sounds like a big undertaking, with all these details
you want to have done at the same time.
And it sounds quite "forced".
Technically it is possible of course, but
the investment would be huge and won't pay off, since there is no
mechanism, by which your engineered bacteria profit
from poisoning disease causing bacteria.
So after a while they will loose this ability,
as well as the diseases becoming resistent.
By "cleaning" the mosquitos they create a habitat,
which will be re-invaded after some time.
What would be the mechanism of spread for your bacteria?
What mosquito-bacteria symbiosis relationships would
you disrupt, thereby motivating the mosquitos to
get rid of your bacteria?
The mosquitos would then also transfer low amounts of
your antibiotic onto the hosts they feed from,
thereby forcing the development of resistant bacteria
in the host as well as in the mosquito.
If all this is answeared, you still have the technical
question how to develop a pathogen that selectively
infects disease spreading mosquitos, inable to mutate
to infect other species, and being biochemically able
to invade and life inside a mosquito, being transfered
from mosquito to mosquito.

Cheers, Matthias


Am Samstag, den 02.06.2012, 01:12 -0700 schrieb Margret Storm:
> Would it be possible to engineer a contagious bacterial strain that
> resided in the digestive tracts of mosquitoes, and had little effect
> other than releasing antimicrobial enzymes into the pharynx and
> salivary glands? Hopefully, this would prevent the spread of
> mosquito-borne diseases like malaria, as well as help prevent
> secondary infection of bites.
>
>
> Forgive me in advance for any ignorance - the idea has been bugging me
> (hah), and I really want to know.

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