Re: [DIYbio] Re: DIYbio projects

This is an interesting thread. At Biocurious, we've been trying to work with Registry parts for a couple months, not much success for a host of reasons.  Personally, I have been pushing for Bioc members to develop our own completely open source library of parts that will be freely available (no IP restrictions) for all to post into and obtain parts from.  We should all work on this together.  The lack of availability of parts is clearly hampering the growth of DIYBio in general.  At Bioc we have people in the lab who (with some training) can work to vet parts and probably maintain them.  I'm not sure about the distribution piece of the puzzle, but building a better web interface and completely and freely available bioparts would be of greater interest to this community than the Registry - as I see it.  I've been willing to spearhead this effort at Bioc, but unfortunately am heading out of the country for a few months so I can't do much (other than have phone conversations) until I return in August.  Mac,  let's try to work on something together leveraging the resources we have at Biocurious.  There is big interest from folks there to get up to speed with working with parts, stepping beyond playing with GFP.

Cameron

On Tuesday, June 5, 2012 8:21:42 AM UTC-7, Cathal wrote:
It's not concern of litigation, it's a matter of source derivation.

Yes, I can "DIY" my own proteins at home for lulz, and nobody will care
if I'm breaking patents.

What about if I give away/sell the plasmids, allowing everyone to break
the patents, and undercut the companies that currently live on
artificial scarcity, imposed by the patents?

Then I get sued. Not only that, their attention turns to derivatives of
the method, to cut off other problems before they appear.

Instead, we come up with "Free-Libre Open Source" DNA and methods, which
can be infinitely derivatised without fear of patent-trolling. It's
elementary, and obvious: this is where we're headed, and distractions
down patent-trollable dead-ends will only waste a lot of our time and
money as a community.

On 05/06/12 16:16, Simon Quellen Field wrote:
> No one is going to sue you for using cold potato starch to purify proteins.
>
> If you give people irrational fear of litigation, they will self-censor and
> not
> do the wonderful things the group is capable of.
>
> Governments give inventors temporary monopolies (patents) on their
> inventions
> in exchange for publication of the details. This is in the public interest
> because
> otherwise the inventor would try to keep those details secret. The purpose
> of the
> patent system is to disseminate knowledge. We are supposed to read the
> patents
> to understand how things work, so we can use that information to produce new
> ideas, inventions, and discoveries.
>
> Companies that own the patents will try to game the system to get the
> benefit of
> the monopoly when the benefit to society would have happened anyway. Prior
> art
> is one way that government decides whether the idea is already public. The
> courts
> are there to protect the interests of society, not to protect the
> corporations, despite
> the uneven playing field caused by corporate wealth.
>
> But consider the case of a company with a patent on potato starch
> purification of
> proteins and a DIYBio member using that method to purify her own proteins.
> Several
> hurdles must be overcome before the DIY biologist is harmed:
>
>    - The company must become aware that someone is using their patented
>    process.
>    - They must decide that suing her is the best use of their resources.
>    - They must prove in court that they have been harmed.
>    - They must collect the damages awarded, which are limited to the damage
>    done plus a punitive amount designed to prevent further harm.
>
> Given that the 'damage' is that the DIY biologist did not pay a few dollars
> for the
> potato starch the corporation sells to be used for this purpose,
> the likelihood of the
> lawsuit ever happening is small. Patent lawsuits are about people *selling *
> other
> people's intellectual property, not *using *it.
>
> -----
> Get a free science project every week! "http://scitoys.com/newsletter.html"
>
>
>
>
> On Tue, Jun 5, 2012 at 3:43 AM, Cathal Garvey <cathalgarvey@gmail.com>wrote:
>
>> I'm working on this. I'd share the idea right away, but I want to
>> implement it first to guarantee that I've established "prior art" beyond
>> reasonable doubt.
>>
>> The problem is, there are great methods out there, but they're patented
>> to oblivion. Consider Maltose-Binding Protein: You could, in principal,
>> just use cold (insoluble) potato starch to purify proteins. But, it's
>> patented in the EU for another few years at least, and possibly in the
>> US for the time being, too.
>>
>> I've got something up my sleeve, but I don't want to put it into the
>> public domain until I'm sure nobody can steal/patent it and prevent it
>> from being used by the community. I'm sure patent apologists will insist
>> that this is unreasonable, but history says it's not.
>>
>> On 04/06/12 21:12, Cory Tobin wrote:
>>>> My suggestions would be:
>>>> - Enzymes commonly used in the lab that would save a lot of money when
>>>> produced by yourself, such as DNA restriction and polymerase, some are
>>>> available
>>>
>>> I like the idea of people being able to produce their own enzymes.  It
>>> would be great if we could produce our own Taq, ligase and the four
>>> BioBrick restriction enzymes (EcoRI, XbaI, SpeI, PstI).  With those 6
>>> enzymes one could not only work with most BioBrick parts but also
>>> bootstrap their lab and produce any additional enzymes they need.
>>>
>>> My main concern with this right now is the lack of inexpensive methods
>>> for purifying the protein.  Most column based methods are expensive
>>> (NTA, etc).  But I don't have much experience purifying enzymes aside
>>> from using kits.  Maybe someone with more experience knows of an
>>> inexpensive method for producing enzymes pure enough to be used for
>>> BioBricks?  This project http://2009.igem.org/Team:Washington/Project
>>> looked really promising but it looks like they never really got the
>>> system working and quit working on it.
>>>
>>>
>>> -cory
>>>
>>
>> --
>> www.indiebiotech.com
>> twitter.com/onetruecathal
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>>
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>


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