On Friday, July 20, 2012 2:50:18 PM UTC+2, Cathal wrote:
should be enough to establish persistence. The fact that it has evolved an iron-free
physiology should be in line with this, too (the other mechanism is to steal iron from
the host via strong siderophores like M. tuberculosis and others).
Whoa, wait: Iron _free_? No Iron at all? That's pretty damned impressive! :D
It is, and so I looked a bit longer at this claim. PMID 9353077 has support for a Fe-SOD in
B. burgdorferi but they didn't try if the same enzyme works with Mn. Then there is PDB 2pyb
which would be a clear counterexample if the paper would have been published by now. The remaining hits in the 1250 gene B. burgdorferi proteome are five putative enzymes where some homologue in other species has iron ions or Fe-S clusters as cofactor. So, even if the claim may not 100% true, which is unclear, it is pretty close.
--
You received this message because you are subscribed to the Google Groups "DIYbio" group.
To post to this group, send email to diybio@googlegroups.com.
To unsubscribe from this group, send email to diybio+unsubscribe@googlegroups.com.
To view this discussion on the web visit https://groups.google.com/d/msg/diybio/-/bzL0OkJ-arcJ.
For more options, visit https://groups.google.com/groups/opt_out.
0 comments:
Post a Comment