Hrmm, I can't seem to find the patent mention.... I'm wondering if that cyclization is spontaneous or not... If not I'd want to search for proteins with a binding pocket shaped like the phenol and phenyl side chains in coelenteramide and coelenteramine (the side away from the amide/amine in the metabolites).
If the cyclization is spontaneous, maybe you could fuse the luciferase to an ubiquitinization enzyme, to immediately mark the luciferin-protein for recycling once it was used for photon emission
.
--
-Nathan
On Wed, Dec 26, 2012 at 9:21 AM, Andreas Sturm <masterstorm123@gmail.com> wrote:
ptide from 64 to 69, so *perha
-Nathan
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