Re: [DIYbio] Re: Oxidative stress: Less harmful than suspected?

It's a fascinating effect, and one that surprisingly few cancer
researchers are aware of. In fact, almost nobody focuses on the Warburg
effect when seeking general purpose ways to target cancer, even though
it's one of the very, very few things that *most* cancers have in common.

It was looking at the Warburg effect that lead to the discovery that
dichloroacetate seems to cause cancer apoptosis; the researchers
screened a number of drugs known to activate mitochondrial pathways in
an attempt to reverse the Warburg effect, and lo-and-behold: DCA lead to
broad-spectrum induction of apoptosis against lots of cancer cell lines.

I wonder what would happen if you gave DCA to Loricifera? :P "SCIENCE!"

On 10/12/12 20:50, Andreas Sturm wrote:
>>
>> And yes, the difference is profound: with oxygen, each Glucose
>> molecule provides (IIRC) 32 units of ATP, whereas without oxygen you
>> only get.. 2? 4?
>>
>
> IIRC, 4 molecules ATP are produced, but two are used to activate the
> reaction. Making netto 2.
>
> Wow, didn't know that about cancer.
> Thanks for the link ;)
>
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> On Mon, Dec 10, 2012 at 9:37 PM, Cathal Garvey <cathalgarvey@gmail.com>wrote:
>
>> Well, fermentation need not produce acid, but most fermentation methods
>> do. And yes, the difference is profound: with oxygen, each Glucose
>> molecule provides (IIRC) 32 units of ATP, whereas without oxygen you
>> only get.. 2? 4?
>> In fact, this is one of the things that makes Cancer so destructive;
>> most forms of cancer do not live by aerobic metabolism anymore, on
>> account of the "Warburg Effect":
>> https://en.wikipedia.org/wiki/Warburg_effect
>> ..as a result, even a small tumour can devour vast amounts of blood
>> glucose compared to a normal body of tissue of the same size, especially
>> considering the high growth rate of cancerous tissues.
>>
>> There is only one genus of "animal", as far as I'm aware, that is known
>> to live without oxygen:
>> https://en.wikipedia.org/wiki/Loricifera#In_anoxic_environment
>> ..and they are quite small and live in sediments in the Med, so they
>> don't make a good example of a large, chordate animal that can survive
>> without oxygen.
>>
>> On 10/12/12 19:26, Andreas Sturm wrote:
>>> Interesting!
>>>
>>> Yeah, I imagine a metabolic pathway where a mammal just does anoxic
>>> metabolism. But the problem is, aerob metabolism gives you by far more
>>> energy. And, they would then produce acids, which they have to get rid
>> of.
>>> The acids may have an effect on lifespan too. Maybe neutralizing the
>> acids
>>> could work by producing bases in parallel? Or exporting the acids in a
>>> natural manner.
>>>
>>>
>>>
>>> On Mon, Dec 10, 2012 at 7:44 PM, Daniel C. <dcrookston@gmail.com> wrote:
>>>
>>>> On Mon, Dec 10, 2012 at 9:34 AM, Mega <masterstorm123@gmail.com> wrote:
>>>>> What would be truely interesting, is to make a mammal live without
>> oxygen
>>>>> and then compare the lifespan/ health in the same age to another oxygen
>>>>> breathing one. But this won't be easy, by far not, I suspect...
>>>>
>>>> This experiment is currently being conducted all over the planet -
>>>> mammals that live at sea level get much more oxygen than those that
>>>> live in, say, the Himalayas. I only know of one mortality study where
>>>> altitude came up as a factor:
>>>> http://www.sciencedaily.com/releases/2011/01/110113131436.htm but I'd
>>>> be interested in learning more.
>>>>
>>>> Also, if you literally meant without *any* oxygen, then that really
>>>> would be a challenge.
>>>>
>>>> -Dan
>>>>
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>>>
>>
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