Re: [DIYbio] Re: Oxidative stress: Less harmful than suspected?

Well, fermentation need not produce acid, but most fermentation methods
do. And yes, the difference is profound: with oxygen, each Glucose
molecule provides (IIRC) 32 units of ATP, whereas without oxygen you
only get.. 2? 4?
In fact, this is one of the things that makes Cancer so destructive;
most forms of cancer do not live by aerobic metabolism anymore, on
account of the "Warburg Effect":
https://en.wikipedia.org/wiki/Warburg_effect
..as a result, even a small tumour can devour vast amounts of blood
glucose compared to a normal body of tissue of the same size, especially
considering the high growth rate of cancerous tissues.

There is only one genus of "animal", as far as I'm aware, that is known
to live without oxygen:
https://en.wikipedia.org/wiki/Loricifera#In_anoxic_environment
..and they are quite small and live in sediments in the Med, so they
don't make a good example of a large, chordate animal that can survive
without oxygen.

On 10/12/12 19:26, Andreas Sturm wrote:
> Interesting!
>
> Yeah, I imagine a metabolic pathway where a mammal just does anoxic
> metabolism. But the problem is, aerob metabolism gives you by far more
> energy. And, they would then produce acids, which they have to get rid of.
> The acids may have an effect on lifespan too. Maybe neutralizing the acids
> could work by producing bases in parallel? Or exporting the acids in a
> natural manner.
>
>
>
> On Mon, Dec 10, 2012 at 7:44 PM, Daniel C. <dcrookston@gmail.com> wrote:
>
>> On Mon, Dec 10, 2012 at 9:34 AM, Mega <masterstorm123@gmail.com> wrote:
>>> What would be truely interesting, is to make a mammal live without oxygen
>>> and then compare the lifespan/ health in the same age to another oxygen
>>> breathing one. But this won't be easy, by far not, I suspect...
>>
>> This experiment is currently being conducted all over the planet -
>> mammals that live at sea level get much more oxygen than those that
>> live in, say, the Himalayas. I only know of one mortality study where
>> altitude came up as a factor:
>> http://www.sciencedaily.com/releases/2011/01/110113131436.htm but I'd
>> be interested in learning more.
>>
>> Also, if you literally meant without *any* oxygen, then that really
>> would be a challenge.
>>
>> -Dan
>>
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