Well, the "problem" is that the hok protein is not secreted, while if they would produce kanamycin, there would be no need for an antibiotic.
Hok/sok just ensures that the cells don't lose the plasmid, but the proportion stays the same: 999 untransformed, 5 Transformed.
But I love Hok/Sok for it's simplicity and smallness of genes... What about another toxin/antitoxin system? I read that relBE also works in yeast IIRC, and is equivalently short.
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