Re: [DIYbio] Linearization / Circularization of Chromosomes

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Well, sure, but every time you induce your many, many tiny benign
tumours will proliferate a little bit. So you also need to sort out how
to kill those guys between treatments.

To me, it seems likely that the model for cancer goes something like:
1) Lots of tiny benign tumours appear throughout life that escape
immune monitoring but hit the hayflick limit and do not become malignant
2) Some of these gradually mutate further and may become immortal
3) Of these, some will continue to escape immune system and become
larger benign tumours, or become malignant and become "cancer".

Some stuff suggests that you can target them early, if this model holds
true (and the "early escape" or "premalignant metastasis" hypotheses
back this model up). For example, there's meta-research suggesting that
even a temporary course of daily aspirin can reduce *lifelong* cancer
risk significantly; in the above model, this suggests that aspirin can
help kill these microtumours or early-escaped premalignancies, reducing
the risk of later further mutation and malignant-isation.

This may also be found true of other lifestyle-anticancer interventions
such as resveratrol/pterostilbene, berberine, etc.

So if you can solve the problem of microcancers and micrometastases,
you can probably also solve the long-term hazard of cancer due to
induction of telomerase, and therefore reduce its contribition to
ageing.

On Fri, 8 Nov 2013 02:02:03 -0800 (PST)
"Mega [Andreas Stuermer]" <masterstorm123@gmail.com> wrote:

> Well, what about expressing telomerase in an inducible manner like
> with tet.? And once a year you get a re-juvenation injection with
> tetracyclin. ^^
>
> So circularization would do the same as constitutive telomerase
> expression?
>