Need for telomerase isn't an accident. If it were a good idea to have active telomerase all the time, we would! But having a limit to replication limits the growth of premalignant tumours.
It's much easier to make telomerase constitutive than to circularise, if your only goal is "longevity".
"Mega [Andreas Stuermer]" <masterstorm123@gmail.com> wrote:
Hi everyone,
I read this, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796773/
The authors (there are many, some people seem to co-autorize all people they know :P ) have combined linear phage replication elements and a usual E. Coli chromosome and got it to be in a linear state.
There also was a newer experiment, http://pubs.acs.org/doi/abs/10.1021/sb400079u where they splited the circular genome in two linear ones. Replicates and grows without problems.
I guess that this is the opposite direction to longevity?
What about the opposite direction? Circularization of human chromosomes? So no telomerase is needed, no shortening of (non.-existent) telomeres?
In the future, I'm gonna try this in yeast, but it has 16 chromosomes :P Isn't there some eukaryote with, say, 2 chromosomes? :D
I guess some IPTG-induced Cre recombinase could cut out the selection marker 16 times...
Just waiting for gene synthesis to get cheaper.
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