I know this is late, but I was looking for thermal degradation data myself and after I found it I figured I would post it here for anyone else that stumbles on this thread:
Ampicillin and tetracyclin are temperature sensitive; kanamycin is heat stable. They did not include streptomycin; however, US patent 2473339 says: "prior to the present invention it was generally known that it was impossible to autoclave solutions of streptomycin and that such solutions were injured by temperatures materially above 75° Fahrenheit" so yes/no for streptomycin but you might not be able to prepare your solutions in the way that they are making them.
On Monday, 31 December 2012 01:11:51 UTC-8, Mega [Andreas Stuermer] wrote:
-- Heat stability of the antimicrobial activity of sixty-two antibacterial agents
J. Antimicrob. Chemother. (1995) 35 (1): 149-154.
doi: 10.1093/jac/35.1.149
Ampicillin and tetracyclin are temperature sensitive; kanamycin is heat stable. They did not include streptomycin; however, US patent 2473339 says: "prior to the present invention it was generally known that it was impossible to autoclave solutions of streptomycin and that such solutions were injured by temperatures materially above 75° Fahrenheit" so yes/no for streptomycin but you might not be able to prepare your solutions in the way that they are making them.
On Monday, 31 December 2012 01:11:51 UTC-8, Mega [Andreas Stuermer] wrote:
Hi everybody,for our GFP - plant project at the AEC we will need Kanamycin, Tetracyclin and Streptomycin.AFAIK, you can autoclave Kanamycin (but never ever ever Ampicillin! ;) ). What about Tetracyclin and Streptomycin, will they degrade @ 121°C and 2 bars?Best,Andreas
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