Supplemental effects
Bergö and his colleague, Per Lindahl, also a molecular biologist at the University of Gothenburg, stumbled into the antioxidant debate accidentally. The team was conducting unrelated experiments in mice that were genetically engineered to develop lung cancer, and decided to dose the mice with NAC as a control. If anything, they thought that NAC might slow the tumours slightly, says Lindahl. Instead, the control tumours grew three times faster than expected. “The real experiment turned out to be a disappointment,” he says. “But the control was quite interesting.”
The team decided to dig deeper, and expanded its study to include another common antioxidant, vitamin E. The researchers fed either NAC or vitamin E to the mice, using doses of 5 or 50 times higher than the daily recommended amount for mice. Human dietary supplements often have 4 to 20 times the recommended daily intake of vitamin E for humans, says Lindahl. The results for the two antioxidants were similar: tumours grew about three times faster than those in animals that did not receive the treatment. Treated mice also died from their cancers about twice as quickly as untreated mice.
>Really ? Do you have sources about that ?
http://www.goodreads.com/quotes/735647-two-large-trials-of-antioxidants-were-set-up-after-peto-s
Two groups of people at high risk of lung cancer were studied: smokers, and people who had been exposed to asbestos at work. Half were given 3-carotene and vitamin A, while the other half got placebo. Eighteen thousand participants were due to be recruited throughout its course, and the intention was that they would be followed up for an average of six years; but in fact the trial was terminated early, because it was considered unethical to continue it. Why? The people having the antioxidant tablets were 46 per cent more likely to die from lung cancer, and 17 per cent more likely to die of any cause,* than the people taking placebo pills.
http://www.ncbi.nlm.nih.gov/pubmed/15572756
The Beta-Carotene and Retinol Efficacy Trial (CARET) tested the effect of daily beta-carotene (30 mg) and retinyl palmitate (25,000 IU) on the incidence of lung cancer, other cancers, and death in 18,314 participants who were at high risk for lung cancer because of a history of smoking or asbestos exposure. CARET was stopped ahead of schedule in January 1996 because participants who were randomly assigned to receive the active intervention were found to have a 28% increase in incidence of lung cancer, a 17% increase in incidence of death and a higher rate of cardiovascular disease mortality compared with participants in the placebo group.On Mon, Feb 10, 2014 at 3:51 PM, Bjonnh <bjonnh-diybio@bjonnh.net> wrote:
On Sun, Feb 09, 2014 at 04:05:56PM +0000, David Murphy wrote:Really ? Do you have sources about that ?
> Trials to test if antioxidants were good for
> your health had to be stopped because so many additional people were dying.
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