Re: [DIYbio] DNA Double Take - NY Times

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Actually, the immunological mechanisms of embryos and cancer are very
alike; cancer makes use of pregnancy-associated immune-modulating
systems very regularly.

In my undergrad years I studied a dull protein called "Murine Pregnancy
Associated Glycoprotein 22". That whole class of glycoproteins are
involved in immune signalling to mothers, saying "please don't kill me,
I'm your offspring".

There's also a global change in immunity in mothers, though that is both
fetal and innate to the mothers' hormone, as I understand it. This
pushes the balance of immune response away from the "adaptive"
(self/nonself) immune response and towards the "innate" response
(complement, macrophages, interferons, etc.), to prevent immune assault
upon the placenta. The side-effect is that pregnant women are far more
susceptible to disease and infection from french cheese! :)

Although I'm not well-read on the longer-term mechanisms, I suspect
there's a pathway or two that mediate negotiations with
antigen-presenting cells, so that they bring baby (or cancer) antigens
to immature T-Cells and induce anergy in any that might attack the baby.

On 25/03/14 22:39, Meredith L. Patterson wrote:
> I'd definitely like to know more about the immune mechanisms involved here.
> (Up to and including recs for good immunology texts, both innate and
> adaptive, particularly with respect to cytokine signalling.)
>
> Cheers,
> --mlp
>
>
> On Tue, Mar 25, 2014 at 11:26 PM, Mega [Andreas Stuermer] <
> masterstorm123@gmail.com> wrote:
>
>>> Women can also gain genomes from their children. After a baby is born,
>> it may leave some fetal cells behind in its mother's body, where they
>> can travel to different organs and be absorbed into those tissues.
>>
>> Someone mentioned not to play around with one's own stem cells because
>> exactly this could happen :D
>>
>> On the other hand, in that case it still are not yor cells, but your
>> childs. That may make the difference why it rather does not evolve into
>> cancer? The ommune system may rather fight your childs cells than yours. On
>> the other hand, how can they even survive then?
>>
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