[DIYbio] Re: Pseudonyms in DIYbio, was: Antioxidant hype

A lotta people on here use fake names, I am using one because its my internet name and I am too lazy to change it. You shouldn't base arguments against that.

My 2 cents on the topic is I agree mostly with Matt, but even if people don't work in your field specifically, their voice should be heard (like playing devil's advocate when planning experiments). On the topic of SENS, yea I'd think that with genetic engineering it would be possible to reduce aging. Since with genetic engineering pretty much anything is possible, it would be helpful to continue experimentation on it. Even just for public appeal, lets take a look at golden rice. The vitamin A degrades in a couple days (excuse me for not citing link, if you'd like it I would be more then happy to provide it, but it took me a while to find the original paper in the first place). However, even though the technology doesn't work to its full potential, it actually shows that SOME good can come out of that research allowing for the public's opinion to be more open to the subject of GMOs, which is a good thing.

First of all, its very possible aging can be reduced through genetic engineering. Lets first look at if a single protein is needed to be mutated (which yes, I KNOW there is probably hundreds). They've done this with HIV

http://nar.oxfordjournals.org/content/early/2013/06/26/nar.gkt571.long

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080757/

To the point where they can (pretty much) make a point mutation in a single protein using an adenovirus (I believe the second paper uses adenovirus, perhaps adeno-associated virus, didn't look this up that closly) packaged with a zinc finger endonuclease. Now days with CRISPR we can probably make these mutation with the repeats, giving up to 20 or so mutations at a single time. (It is well known that CRISPR can do that, just look it up on like addgene they give very good overviews).

If we assume that 10 proteins are required to be mutated to slow aging in a certain cell line (such as bone marrow, but note I am a bacterial synthetic biologist, I know mostly about how to manipulate DNA so potentially a different cell line could be used, this is just for the sake of argument) Lets say when injected it infects 5% of cells. Within 10 injects, a good amount of the population will be mutated to the point of where this treatment could become hypothetically useful

Not saying this will happen (I engineer bacteria genomes, not eukaryotic genomes) but there is always a possibility for discovering genes that are associated with aging, and if mutations are found to extend it then genome engineering might be able to do this. Anywho I don't know that much about the other topics, so I'll leave that alone

-Koeng

On Thursday, April 24, 2014 1:03:36 AM UTC-7, Cathal Garvey wrote:

I don't like this:

> Because whether you are deluded enough or not to believe Reason is
> your real name, or went to the insane length of changing it legally,
>  your so called "privacy" is a smokescreen

..If people on the list disagree, let them disagree. But attacking
people because of their pseudonym or name is inane bullshit.

> I'm also averse to people hiding behind a pseudonym meant to convey
> how much smarter or more logical they are.

You'll notice that a staple of this list goes by the 'nym "Mega": is he
to be denounced, then?

Frankly I don't give a crap what name people go by, and I've never
understood the venom directed at Reason for his name, irrespective of
whether or not it's real. I simply don't give a toss, and I'm boggled
that anyone does.

Please keep discussions on the topics and the science; if one or the
other presents no compelling evidence, then they'll be ignored. Simples.
But do remember that's a luxury;

> no one with common sense believes someone who says "I have all the
> facts, but they are private and I won't share, trust me".

..actually, the level of sense that prevents people believing secret,
unsourced BS is fairly rare.

On 24/04/14 00:26, Some People wrote:
> Bickering

--
T: @onetruecathal, @IndieBBDNA
P: +353876363185
W: http://indiebiotech.com