Maybe I'm missing something, as I haven't been following this thread from the beginning, but if your heater has to heat and cool the aluminum as well as the sample, the problem you are trying to solve is exacerbated, not alleviated. If you are moving the sample from a hot aluminum block to a cold one, then you are fine. Otherwise, you'd want low thermal mass, and air is pretty good. So would be a design that moved hot and cold water into the space around the sample. The water is a good heat conductor, and it is easy to keep large reservoirs of water at a constant temperature, and then move small amounts of water at the proper temperature into a chamber full of samples. Two valves, and gravity can move the water from the reservoirs through the device and into the sink.
Pretty cheap.
On Mon, Jun 30, 2014 at 5:45 PM, Cory Tobin <cory.tobin@gmail.com> wrote:
> Having a non-block with zero mass is even better.Sure, except that air doesn't transfer heat to your sample nearly as
fast as aluminum. Imagine putting your hand in a 100C oven vs putting
your hand on a 100C frying pan. That's why most thermalcyclers take
into account the volume of the sample and calculate the temperature
instead of just using the temperature of the block.
I'm not saying air won't heat the tubes sufficiently fast. If you are
optimizing for cost then air is the way to go. But heating and
cooling the air rapidly won't necessarily lead to the temperature of
the sample being heated/cooled faster compared to aluminum.
-cory
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