[DIYbio] Re: Ah great, just found a small and safe gene therapy against herpes virus and similar skin viruses

The cells in the dermal layer don't get continuously replaced, IIRC. You can probably find the relevant details with a little googling.

The bigger question is: what do you want to achieve? Even if you stably introduce an expression construct into some dermal cells, it's going to be hard to have an impact on anything other than the immediate area. Such a few cells will not express enough protein to have a systemic effect.

At least, not for most proteins. One exception is expressing vaccine antigens to try to generate an immune response. That doesn't need much expression. But a LOT of professional effort has gone into intadermal DNA vaccines, with essentially no significant success.

Which isn't to say that your idea can't do better. Just to warn you that there will be hurdles.

Good luck!

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