[DIYbio] Re: Localising Gene Therapies?

Btw,

Adenoviruses can trigger an immune response. Better use Adeno-Associated virus.

Just hypothetically speaking





On Wednesday, July 23, 2014 3:32:54 AM UTC+2, Jarrad wrote:

Hey Guys

Unsure if this is an appropriate place to ask, if not, please refer me elsewhere more suited.

I have been reading a handful of papers on optogenetics, one of them went into the "leakage" of the adenovirus therapy, showing that whilst the target zone was predominantly affected, expression was found in other organs in the body, marginally.

Say, hypothetically, if I wanted to target Merkel cells in a specific region of a skin tissue sample, is there any methods to specifically target them without affecting other Merkel cells? They aren't too deep in the tissue so maybe some topical treatment is possible?
Or some kind of treated skin graft?

Oh and don't worry I know this is diybio, I don't actually expect to be carrying out this experiment (especially not in my garage :D) I really would like some help to see if this is possible

Thanks!