[DIYbio] Re: Bioinformatic tool -> berberine binding to enzymes

Small Poblem...

I put the resulting file into Hex for visualization (did online analysis while downloading)

AAAnd this is what I get :/ An interactive 3D map. No binding value as in this paper

Anti-proliferative and metastatic protease inhibitory activities of protoberberines: An in silico and in vitro approaches



Am Mittwoch, 6. August 2014 15:27:00 UTC+2 schrieb Mega [Andreas Stuermer]:
Hi! 

Could use some help with the following: 
One mode of action is that berberine and derivates activate cbl-ubiquitin ligase. Now I was told to identify structures where berberine binds to. So maybe to cbl, or some upstream protein.

I don't know of any bioinformatic tool that is advanced enough to solve this. Does anyone know of one? 

Best,
Andreas  

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