I would recommend doing something with either bacteria or insects.
-- It is really good to find a problem and then think about ways of using bacteria to solve that problem. Often the more interesting problems come from third-world countries, and biohacking is awesome becuase oftne your approach will below cost so is transferrable to them.
Try searching what problems exist and make a list. You might want to looks for problems that are qualitative or quantatitve; ie detcting the presennce of something, or measuring how much of something is around. These are really good becuase if the approach is new, even if it doesn't work super well, you can still demonstrate that it works. It can also opne up new ways of thinking about other problems.
I hope that helps!
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