Re: [DIYbio] Re: least risky human hello world?

On Sun, Sep 14, 2014 at 2:16 PM, Andreas Stuermer
<masterstorm123@gmail.com> wrote:
> Well silencing RNA very very likely won't trigger an immune response.

Hmm, yeah, that's a good point.

> Usually it takes protein structures for antibodies to recognize. To put it
> that way it would be safer than putting GFP in your skin.
> GFP is a foreign protein and your immune system may some day recognize the
> GFP and kill all cells that carry it. Bad if they already make up like 5% of
> your skin. Necrosis.
>
> I think the influenca silencing would be the safest diy hello world
> transhumanist project xD

While it might be safe in its mechanism, think about how to get the
result. You'd have to go try to get sick with flu, if you don't end up
sick, maybe it worked, or maybe you were around the wrong people or
your body was already immune.... but if it doesn't work then you get
the flu and are sick.

That doesn't sound like a fun/benign test/experiment. :)

>
> Second opinions?
>
> Btw, you say in America I am allowed to genetically alter my skin cells or
> lung cells?


Yeah I am mostly sure, as long as you're following all the laws
regarding chemical storage and disposal, buying all your reagents
through unobfuscated channels (i.e. you have a business license, and
the owner/landlord of the building the lab is in knows you are doing
lab work). You only have to do moral/ethical reviews when part of an
institution or asking /other/ people to get experimented on (AFAIK).

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