Re: [DIYbio] Re: least risky human hello world?

Well silencing RNA very very likely won't trigger an immune response. Usually it takes protein structures for antibodies to recognize. To put it that way it would be safer than putting GFP in your skin. 
GFP is a foreign protein and your immune system may some day recognize the GFP and kill all cells that carry it. Bad if they already make up like 5% of your skin. Necrosis. 

I think the influenca silencing would be the safest diy hello world transhumanist project xD  

Second opinions? 

Btw, you say in America I am allowed to genetically alter my skin cells or lung cells? 

On Sun, Sep 14, 2014 at 9:50 PM, Nathan McCorkle <nmz787@gmail.com> wrote:


On Sep 14, 2014 4:18 AM, "Mega [Andreas Stuermer]" <masterstorm123@gmail.com> wrote:
>
> Want to be resistant to influenza for life? Influenza usually propagates in the lungs. Express silencer RNA against few influenza-proteins. Delivery method: http://www.pnas.org/content/93/21/11454.full.pdf 
>
> Use a vector that doesn't integrate (potentially giving you cancer). 
>
>
> Would that count as a "hello world"?

Hello world is usually simple enough that it works, but simple and benign enough not to cause much difficulty.

Working with disease or immune response is a little far from the simplicity I'd be comfortable with trying.

> Btw, it is illegal in most of the world.

What do you mean? In the U.S. unless a chemical is on the scheduled list, I'm pretty sure it's free to be used internally. I wonder if the NRA (gun rights advocates) would support gene guns as a constitutionally-protected implement.

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