Hi Mega,
I think we are talking about different things. We can agree that the immune system will probably eliminate luciferase-expressing cells. For a small patch, transient transfection, this may uncomfortable, but on its own not very dangerous.
The more dangerous concern is development of an autoimmune disease targeting self-antigens, not the transgene. This could occur if there is homology to a self protein, or if the immune system randomly breaks tolerance to an unrelated self-antigen in the skin (a minor risk for inflammation in general). My argument is (1) there is a risk, (2) at first assessment the risk looks small, (3) more risk-assessment needed before trying it.I think we are talking about different things. We can agree that the immune system will probably eliminate luciferase-expressing cells. For a small patch, transient transfection, this may uncomfortable, but on its own not very dangerous.
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