In certain cases I'd hope single founder applicants wouldn't be seen as a liability to investors otherwise I'm SOL. In many cases its hard to find someone else willing to suffer alongside you in pursuit of the real deal. Everyone wants to be an entrepreneur, but not everyone wants to sell their personal belongings to buy synthesis reagents instead of beer. Everyone wants to be a millionaire, but not everyone wants to end the lease on their apartment to sleep on a blow up mattress in order to buy time on an LCMS. Being alone doesn't mean you're a bad scientist, it means you haven't found someone else willing to bleed as much as you.
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