Re: [DIYbio] Making the MOST addictive chocolate on the planet - BUT which substances should I use???

On Wed, Nov 26, 2014 at 6:14 AM, Amy Meevis <amymeevis@gmail.com> wrote:
> Dear DIYbio community,
>
> I am currently doing an internship at Waag Society's Wetlab in Amsterdam
> (The Netherlands) and I have been doing research on food addiction and
> addictive substances in food for the past couple of months. My background is
> in Design, so I'm not really familiar with the in's and out's of
> (DIY)biology, what protocols to use and which direction to look at.. So.. I
> need your help!
>
> The proposal I've come up with so far is to create a piece of chocolate that
> blurs the boundaries between food and drugs, making use of several
> stimualting and addictive substances found in other foods (or even
> syntetically created substances). The idea is that these additives consumer
> such a satisfactory experience that only one biteful will be enough to stop
> the craving for chocolate.

Being satisfied and being addicted are sort of exact opposites. There
are movies made about some addict's 'last drink' etc... and they
always get sucked into addiction further. I think you need to better
define your goals, at least for us, since it is hard to interpret.

If you really want super-addictive, it would probably be some
combination of methamphetamine, barbiturates, fentanyl, and cocaine.
There are likely synthetic analogues that are much more intense, but
I'll leave that search up to you (hint, search:
[chemical_name_or_class] agonist).

Sugar as-is is already quite addictive, so if you're really after
SATISFACTION (which addictive substances do not give for more than a
few fleeting moments) you might look at ways to replace the sugar
content with some sweetener which does not affect the insulin response
(cepalic system)... but I don't think that will be an easy feat
whatsoever.

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