Re: [DIYbio] diy MRSA antibiotic using garlic, reproduced in lab

That news headline was spectacularly out of scale with the significance
of the news. Bile salts, red wine (alcohol), allicin and various other
volotiles, and in-vitro or on topical application it kills bacteria.
AMAZING! Except that topical alcohol alone will achieve the same with
less complexity and fewer chances of allergy or skin reaction.

This doesn't amaze so much for external uses, because your options for
external treatment are so much broader already. Even for eyes, you can
be a bit more brutal than you can be with a pill, and there are whole
classes of antibiotic that can be used externally that are inappropriate
or useless for internal uses.

The problem with internal antibiotics isn't killing MRSA, that's
trivial. It's killing MRSA and co *inside the body* using agents that
are effective, selective, and safe. If you eat that cocktail it's highly
unlikely to be effective, it'll be at least partially selective, and
it's likely to be safe, by my guesstimate. It's hardly a blockbuster,
but it's interesting to see the kinds of work they did back when
distillation wasn't commonplace and poultices needed that extra oomph to
make up for insufficient alcohol.

On 01/04/15 01:04, leaking pen wrote:
> Yeah.. I'm not sure what the surprise is. It reminds me of George
> Carlin bit about "happens to be black". Allicin is one of the first
> sulfa antibiotics we used, and is a direct extract from Garlic. With
> the salts and such that are in there, you're basically breaking down the
> fats and protiens and extracting it, and Sulfa drugs have already been
> shown to be amazingly effective on Mersa (and yet no one prescribes
> it... sigh)
>
> The wonder of the whole thing is how detailed the process is for the
> time frame, not that it works.
>
> On Tue, Mar 31, 2015 at 4:46 PM, Jonathan Cline <jcline@ieee.org
> <mailto:jcline@ieee.org>> wrote:
>
> Today's big pharma ain't got nuthin on 9th century Anglo-Saxon diybio?
>
>
>
> ""A one thousand year old Anglo-Saxon remedy for eye infections
> which originates from a manuscript in the British Library has been
> found to kill the modern-day superbug MRSA in an unusual research
> collaboration at The University of Nottingham.""
>
> Bald's eye salve [as listed in BBC news article, see ref below]:
>
> Equal amounts of garlic and another allium (onion or leek), finely
> chopped and crushed in a mortar for two minutes.
>
> Add 25ml (0.87 fl oz) of English wine - taken from a historic
> vineyard near Glastonbury.
>
> Dissolve bovine salts in distilled water, add and then keep chilled
> for nine days at 4C.
>
>
>
> ...
> "" Early results on the 'potion', tested in vitro at Nottingham and
> backed up by mouse model tests at a university in the United States,
> are, in the words of the US collaborator, "astonishing". The
> solution has had remarkable effects on Methicillin-resistant
> Staphylococcus aureus (MRSA) which is one of the most
> antibiotic-resistant bugs costing modern health services billions. ""
>
> Ref: University press release
> http://www.nottingham.ac.uk/news/pressreleases/2015/march/ancientbiotics---a-medieval-remedy-for-modern-day-superbugs.aspx
>
>
> BBC News article
>
> http://www.bbc.com/news/uk-england-nottinghamshire-32117815
>
> """ A 1,000-year-old treatment for eye infections could hold the key
> to killing antibiotic-resistant superbugs, experts have said.
> Scientists recreated a 9th Century Anglo-Saxon remedy using onion,
> garlic and part of a cow's stomach. They were "astonished" to find
> it almost completely wiped out methicillin-resistant staphylococcus
> aureus, otherwise known as MRSA. Their findings will be presented at
> a national microbiology conference. The remedy was found in Bald's
> Leechbook - an old English manuscript containing instructions on
> various treatments held in the British Library. Anglo-Saxon expert
> Dr Christina Lee, from the University of Nottingham, translated the
> recipe for an "eye salve", which includes garlic, onion or leeks,
> wine and cow bile."""
> ...
>
> "" The team's findings will be presented at the Annual Conference of
> the Society for General Microbiology, in Birmingham."
>
>
>
> ## Jonathan Cline
> ##jcline@ieee.org <mailto:jcline@ieee.org>
> ## Mobile:+1-805-617-0223 <tel:%2B1-805-617-0223>
> ########################
>
>
>
> --
> -- You received this message because you are subscribed to the
> Google Groups DIYbio group. To post to this group, send email to
> diybio@googlegroups.com <mailto:diybio@googlegroups.com>. To
> unsubscribe from this group, send email to
> diybio+unsubscribe@googlegroups.com
> <mailto:diybio%2Bunsubscribe@googlegroups.com>. For more options,
> visit this group at https://groups.google.com/d/forum/diybio?hl=en
> Learn more at www.diybio.org <http://www.diybio.org>
> ---
> You received this message because you are subscribed to the Google
> Groups "DIYbio" group.
> To unsubscribe from this group and stop receiving emails from it,
> send an email to diybio+unsubscribe@googlegroups.com
> <mailto:diybio+unsubscribe@googlegroups.com>.
> To post to this group, send email to diybio@googlegroups.com
> <mailto:diybio@googlegroups.com>.
> Visit this group at http://groups.google.com/group/diybio.
> To view this discussion on the web visit
> https://groups.google.com/d/msgid/diybio/551B31CF.5010401%40ieee.org
> <https://groups.google.com/d/msgid/diybio/551B31CF.5010401%40ieee.org?utm_medium=email&utm_source=footer>.
> For more options, visit https://groups.google.com/d/optout.
>
>
> --
> -- You received this message because you are subscribed to the Google
> Groups DIYbio group. To post to this group, send email to
> diybio@googlegroups.com. To unsubscribe from this group, send email to
> diybio+unsubscribe@googlegroups.com. For more options, visit this group
> at https://groups.google.com/d/forum/diybio?hl=en
> Learn more at www.diybio.org
> ---
> You received this message because you are subscribed to the Google
> Groups "DIYbio" group.
> To unsubscribe from this group and stop receiving emails from it, send
> an email to diybio+unsubscribe@googlegroups.com
> <mailto:diybio+unsubscribe@googlegroups.com>.
> To post to this group, send email to diybio@googlegroups.com
> <mailto:diybio@googlegroups.com>.
> Visit this group at http://groups.google.com/group/diybio.
> To view this discussion on the web visit
> https://groups.google.com/d/msgid/diybio/CAFaFt-Tdc26gN8vgXvwLjX1Y7G4sN%2BvgYqno0TNmmMwYrxV8eQ%40mail.gmail.com
> <https://groups.google.com/d/msgid/diybio/CAFaFt-Tdc26gN8vgXvwLjX1Y7G4sN%2BvgYqno0TNmmMwYrxV8eQ%40mail.gmail.com?utm_medium=email&utm_source=footer>.
> For more options, visit https://groups.google.com/d/optout.

--
Scientific Director, IndieBio Irish Programme
Got a biology-inspired business idea that $50,000 -
& 3 months in a well equipped lab could accelerate?
Apply for the Summer programme in Ireland:
http://indie.bio/apply-to-ireland
Twitter: @onetruecathal
Phone: +353876363185
miniLock: JjmYYngs7akLZUjkvFkuYdsZ3PyPHSZRBKNm6qTYKZfAM
peerio.com: cathalgarvey

--
-- You received this message because you are subscribed to the Google Groups DIYbio group. To post to this group, send email to diybio@googlegroups.com. To unsubscribe from this group, send email to diybio+unsubscribe@googlegroups.com. For more options, visit this group at https://groups.google.com/d/forum/diybio?hl=en
Learn more at www.diybio.org
---
You received this message because you are subscribed to the Google Groups "DIYbio" group.
To unsubscribe from this group and stop receiving emails from it, send an email to diybio+unsubscribe@googlegroups.com.
To post to this group, send email to diybio@googlegroups.com.
Visit this group at http://groups.google.com/group/diybio.
To view this discussion on the web visit https://groups.google.com/d/msgid/diybio/551BD50B.7000601%40cathalgarvey.me.
For more options, visit https://groups.google.com/d/optout.