Re: [DIYbio] Viewing bacteria on a molecular level, how to do molecular modeling, and seeking beginner guidance

That's what I meant. It should be easier to take a pore forming domain from colicin and attach it to a domain that binds a - very conserved - receptor of your target bacterium. So it should bind your bacteria, make a hole in the membrane (many molecules -> many holes) and the bacterium dies.

Sounds easier than de-novo design. And you don't have to watch bacteria for that. You can test protein interactions with various methods, and if you take a very conserved protein (usualy phages choose them as their target), you might end up with somethingthat works.

I hope that's helpful!

--
-- You received this message because you are subscribed to the Google Groups DIYbio group. To post to this group, send email to diybio@googlegroups.com. To unsubscribe from this group, send email to diybio+unsubscribe@googlegroups.com. For more options, visit this group at https://groups.google.com/d/forum/diybio?hl=en
Learn more at www.diybio.org
---
You received this message because you are subscribed to the Google Groups "DIYbio" group.
To unsubscribe from this group and stop receiving emails from it, send an email to diybio+unsubscribe@googlegroups.com.
To post to this group, send email to diybio@googlegroups.com.
Visit this group at http://groups.google.com/group/diybio.
To view this discussion on the web visit https://groups.google.com/d/msgid/diybio/8daa4605-4fe0-4f48-9620-bec06ed63c94%40googlegroups.com.
For more options, visit https://groups.google.com/d/optout.