I realize this conversation is four years old, but wanted to add some thoughts:
I've been working on a few side projects that I think could come together to make an affordable Open Source (L)SPR system:
1. An electrospray (for depositing gold nanoparticles) based off of https://www.youtube.com/watch?v=6vvaH8qh-pE
2. A Digital Magnetofluidics platform for fluid handling (https://www.youtube.com/watch?v=BcvYls7hAnI)
3. An electromagnet with laser diode in the centre. (As the electromagnets are the equivalent to my "Fluxels" in digital biology devices)
For this to work I've made a couple assumptions:
1. That Electrospray is sufficient for gold nanoparticle deposition in LSPR applications
2. That I can deposit the particles on top of a hydrophobic coating
When placed over a hydrophobic surface, the iron forms a ring around the droplets in the shape of the electromagnet, leaving the centre transparent, so there shouldn't be any problem with the particles blocking the diodes or binding with the nanoparticles.
If this works, there are a few additional benefits then just cheap gold coated flow cells: Each electromagnet can have a different functionalized gold particle, making it ideal for proteomics applications.
I would love to hear people's thoughts, and if this is something worth pursuing.
Here are some videos regarding Digital Magnetofluidics:
https://www.youtube.com/watch?v=BcvYls7hAnI
https://www.youtube.com/watch?v=u1edy-7Ai2A
Thanks!
Lucas (The Brainery)
On Thursday, March 6, 2014 at 12:52:23 PM UTC-5, Ryan Denomme wrote:
Are people interested in a very low cost surface plasmon resonance tool for biomolecular interaction analysis? Is there a need to develop a low cost tool that any lab/researcher could afford?Think OpenPCR but for SPR.Thoughts?Ryan
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