RE: only new neurons
On Friday, September 20, 2019 at 3:23:39 AM UTC+2, louie anderson wrote:
On Friday, September 20, 2019 at 3:56:06 PM UTC+2, ruphos wrote:
On Friday, September 20, 2019 at 3:23:39 AM UTC+2, louie anderson wrote:
...on top of the fact that if you do this via genetic egineering than only the new nerve cells will exhibit the traits you are looking for
On Friday, September 20, 2019 at 3:56:06 PM UTC+2, ruphos wrote:
The "new cells" are the cells that have been altered via CRISPR to have whatever the new material you inserted. Existing neurons won't be affected. So while adult neurogenesis does happen, the maximum effect (assuming it even worked) is going to be restricted to newly grown cells.
This doesn't sound right to me. Why would your neural stem cells have been affected by your attempt at adult genetic modification, but your ordinary neurons have been passed over? Unless you're injecting pre-modified stem cells into the brain rather than modifying existing cells with a viral vector or something.
If you can modify the DNA of existing neurons, then my judgment is that you should see the changes in the phenotype even of existing neurons. You don't need to regrow the cell from scratch for the new DNA to be used; it would only take so long as the turn-over rate of your receptor proteins, which I think isn't that long. If you cannot modify existing cells, then you're not going to get anything at all into the brain without a surgey-requiring stem cell transplant, not even when new neurons mature.
RE: D-cycloserine
On Monday, September 23, 2019 at 10:27:16 AM UTC+2, Darlene Aldente wrote:
RE: D-cycloserine
On Monday, September 23, 2019 at 10:27:16 AM UTC+2, Darlene Aldente wrote:
Check out D-Cycloserine. a search of "d-cycloserine and addiction" in pub med or google scholar will give you a ton of recent peer reviewed articles. This is an old tuberculosis antibiotic that has been discovered to act on the glutamate receptor int the brain which is central to the neuroplasticity disruption associated with addition. It has shown real results when combined with CBT and the CBT sessions are times with ingestion of the drug. Same method has shown great results for war related PTSD. because the drug increases neuroplasticity, and for other reasons, it has a measurable positive effect on learning (if only I had this drug in college). You Do NOT need to take the full tuberculosis dose, just half. Also, I'm not sure about the duration of treatment.There is one BIG problem however: the cost. This drug has recently fallen prey to opportunistic "investors." in 2015 the price of cycloserine increased from $500 for 30 pills to $10,800 Rodelis Therapeutics purchased it. Purdue University, the previous owner, which retained "oversight of the manufacturing operation" intervened and Rodelis returned the drug to an NGO of Purdue University foundation whi8ch now charges $1,050 for 30 capsules. If you discover a way to use the NGO system through wich governments and non-profits obtain the drug for a fraction of the price please let us know!!
If the OP were interested in this and the cost were the main obstacle, I'd suggest just going with D-serine instead. It has the same neural mechanism of action and some similar experimental results in cases when both have been used in the same type of experiment, which I'm NOT claiming includes addiction. It's available as a nootropic supplement and ridiculously affordable by comparison; plus, you avoid taking needless antibiotics. I researched this question moderately thoroughly for a tDCS project at some point.
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