Frank,
A quick Google search for 'oral microbiota transplant' yielded at least 2 relevant hits:
My suggestion would be to figure out what has been done already, summarize it as would at a lab meeting, in 3-5 slides,
then figure out what has NOT been done yet, and proceed from there.
It's quite possible you've completed all of those steps already, in which case, I'd be curious to read your summary on
current state of the art and what you intend to do specifically...
i am assuming you'd want to perform NGS analyses of the
healthy donor
recipient pre-transplant
recipient post-transplant (how many time points)
as you pointed out, from what specific dental location would the donor sample be obtained from?
as you also pointed out, to what specific dental locations would the donor samples be transplanted to?
So many questions.
Initially, when I read your brief one liner intro email, I was alarmed because I thought it's been established that
dental plaque is the same type of plaque that is responsible for arterial disease etc.
Then I realized 2 mistakes in my quick reading:
1. You are planning to transplant from healthy donor to diseased (PD) individual, NOT the other way around.
2. The jury is still out on whether plaque from PD is caused or simply correlated or not even that with respect to arterial plaque.
I am neither a dentist nor a medical doctor, but as a scientist I'd be very curious to know more about how your background research
has molded your research hypothesis and protocol(s) thus far. Good luck!
- Tom
On Wed, Mar 17, 2021 at 6:13 PM Frank <fgarcia0007@gmail.com> wrote:
--thanks! so what if you're not a dentist , some of this is common sense or basic science so any feedback is welcome------ Original Message ------From: "Inigo Howlett" <inigowalkerhowlett@gmail.com>To: "DIYbio" <diybio@googlegroups.com>Sent: 3/16/2021 10:28:18 PMSubject: [DIYbio] Re: Oral microbiota transplant
cool idea, sadly I'm not a dentist--On Thursday, March 11, 2021 at 5:55:26 PM UTC-5 Frank wrote:Any dentists, periodontists, or dental school students out there willing to participate in a safe and exciting experiment? It involves taking a small amount of dental plaque from a healthy donor who is relatively free of caries and shows no signs of periodontal disease, then putting that plaque into the mouth of a recipient (who does suffer from PD). This would be done with the purpose of having the donor plaque bacteria colonize the recipient's mouth.please let me know
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