Re: [DIYbio] Can a plasmid contain antibiotic synthesis and resistance genes?

I would think for large scale production of certain antibiotics, they would do scale up fermentation of an organism containing the necessary genes.  In some cases, the organism which lead to the discovery of the particular compound might not be the choice organism to do the scaled up fermentation in.  So in that case, I do wonder if companies simply provide that resistance gene + production gene in the form of a plasmid, or if they actually put it into the genome of the organism and create a mutant strain.  I'm not 100% positive but I think it'd be towards creating a mutant, since I imagine plasmids could be diluted out of the population, so to speak, over the course of the fermentation.

I think they've done it with yeast for brewing etc, though that could just be years of selection pressure, not direct genome manipulation.

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