Re: [DIYbio] Re: Can a plasmid contain antibiotic synthesis and resistance genes?

Slight distinction between toxin/antitoxin systems and antibiotics
though; the latter will kill neighbouring cells that don't harbour the
plasmid, whereas the former will only kill a carrying cell if it loses
the plasmid. There will be a certain number of survivors anyway, who
survive the toxin by chance, good timing, or mutation.

On 31/01/13 07:21, Patrik D'haeseleer wrote:
> Have a look at toxin-antitoxin systems
> <https://en.wikipedia.org/wiki/Toxin-antitoxin_system>, which are often
> found on plasmids. If the toxin degrades slower than the antitoxin, this
> prevents the plasmid from getting lost from the bacteria - a nice
> "selfish gene" scenario.
>
> On Tuesday, January 29, 2013 1:33:55 PM UTC-8, Nathan McCorkle wrote:
>
> Such that it would first start expressing resistance, which would
> trigger antibiotic production. The cell would be protected from the
> antibiotic, and as long as the antibiotic was pumped out (maybe the
> resistance is an efflux pump) it would only kill neighboring
> non-transformants.
>
> This would eliminate the need for buying antibiotics.
>
> --
> -Nathan
>
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