Just a suggestion regarding ligation - instead of dealing with blunt ends you might have good luck adapting a TA Cloning protocol (adding complementary 3' overhangs to insert and vector), depending on whether you have the necessary enzymes/reagents. This mitigates low efficiency and backbone recircularization as sources of error (the latter may also be addressed with a dephosphorylation step). Keep in mind that the result will still require screening as ~50% of the products will have inserts reading in the wrong direction (I haven;t looked at the expression vector to see if this matters).
Best,
Paul
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