Re: [DIYbio] Re: Longecity: a crowdfunding strategy worth watching

But it seems to be difficult to correct all the mt -genes. There are many mt per cell.    

You can take a look at some of the open access publications on mitochondrial gene therapy to see whether that's actually the case:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829286/

http://www.discoverymedicine.com/Shilpa-Iyer/2013/03/22/novel-therapeutic-approaches-for-leber-s-hereditary-optic-neuropathy/

I think it's probably harder at this point to measure the degree to which the genes are taken up by mitochondria than to deliver the genes in the first place. Researchers are definitely showing that they can add genes to mitochondria in significant numbers, though:

"Nine to 11 weeks after single exposures to MTD–TFAM + mtDNA complex, PD cybrid cells with impaired respiration and reduced mtDNA genes increased their mtDNA gene copy numbers up to 24-fold, mtDNA-derived RNAs up to 35-fold, TFAM and ETC proteins, cell respiration, and mitochondrial movement velocities."

Reason