Re: [DIYbio] Re: Longecity: a crowdfunding strategy worth watching

On 09/24/2013 03:34 PM, Nathan McCorkle wrote:
> On Sep 24, 2013 4:22 AM, "Reason" <reason@fightaging.org> wrote:
>> It isn't quite a random process. Per the mitochondrial free radical
>> theory of aging there are only thirteen important mitochondrial genes in
>> this mechanism, where damage will lead to a particular set of electron
>> transport chain defects that cause defective mitochondria in the herd to
>> evade quality control via mitophagy and outcompete non-defective
>> mitochondria, taking over the cell.
>>
>> Other mutations don't have that effect, and so will be winnowed.
>>
>> There's a layman's summary here:
>>
>> https://www.fightaging.org/archives/2006/10/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php
> 2006? Surely tons more data has been produced in that time, no?

If this was a field as well funded as stem cell research then that would
be a reasonable expectation. But it isn't. The mitochondrial free
radical theory in its current form is a 1990s thing, and the data
gathered since then really just allows people to argue in more detail
about how exactly its epicycles work. The big picture of the theory
hasn't much changed in that time.

The only people who really care about mitochondrial mutations are (a)
some biogerontologists, low budget, not many of them, and (b)
researchers working on rare conditions like LHON that are caused by
inherited mitochondrial mutations, and again there isn't much money or
interest there in comparison to the mainstream.

Reason

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