Have thought about it, but I think it's out of our reach for now: viruses can mutate their proteins to fit into one another, but the sort of protein structure/function prediction software you'd need to mimic isn't out there yet. We can only reliably substitute synonymous codons without changing protein peptide sequence, which is far more limited.
Koeng <koeng101@gmail.com> wrote:
Yep, but you can change codons to make them like fit into each other, maybe someone would make a program to do it
On Friday, December 13, 2013 2:52:03 PM UTC-8, Mega [Andreas Stuermer] wrote::D You mean only the UTR may be modified, from ATG everything on must be original?Changing codons (for same amino acid) allowed?On Fri, Dec 13, 2013 at 11:46 PM, Koeng <koen...@gmail.com> wrote:We should have a contest of who can put the maximum amount of information in a DNA molecule, with the rule that the genes it uses have to be natural
On Friday, December 13, 2013 2:42:55 PM UTC-8, Mega [Andreas Stuermer] wrote:I'm sure you could also include a -35 promoter element in that :P then it has four meanings. And a restriction site :D
On Fri, Dec 13, 2013 at 11:24 PM, Koeng <koen...@gmail.com> wrote:
When I read the media release, at first I was like "wow!" But then I actually caught onto what they where saying... and then I just did this - http://i.imgur.com/ZRMeE.gifBut then again, it may be beneficial. If you think about it, going over the top on how important something is when talking to the public may get you more funding, which is likely the purpose of the release. So, I guess, in that sense it is doing its job.Anyway, if you want something even more amazing, here is a DNA with triple functionAGGAGTGATGTAATGThe beginning is the Shine-Dalgarno sequence, (bold) and the beginning of a new gene in bold as well. Then italicized is 2 stop codons for 2 different CDSs! That means this DNA has information for 2 CDSs AND a ribosomal binding site! "Where's my nobel prize?" :)(For clarification, this sequence came from phiX174, which is known for overlapping DNA sequences. http://www.ncbi.nlm.nih.gov/nuccore/NC_001422.1 ) -Koeng
On Friday, December 13, 2013 5:18:22 AM UTC-8, Mega [Andreas Stuermer] wrote:
Didn't have time to read it, but may I cite rule16 from http://www.reddit.com/r/science/comments/1sqj63/scientists_d iscover_second_code_hiding_in_ dna/
The "double meaning" is simply silly overblown language saying that a sequence of DNA base-pairs might simultaneously be exonal AND regulatory AT THE SAME TIME (in a way that shows a unique pattern of conservation).
Well, even I could have told you that "double function" :P
Here on this list it was mentioned several times that the ribosome binding sites of viral genes are often found in the terminal of the previous coding sites. Also in the lux genes this occures. Where's our nobel prize? ^^
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