Re: [DIYbio] Re: "Scientists discover double meaning in genetic code" - an interesting article

Viruses win - lots of examples of overlapping genes with coding regions in different reading frames. Now *there*'s an impressive trick!

On Friday, December 13, 2013 2:46:49 PM UTC-8, Koeng wrote:

We should have a contest of who can put the maximum amount of information in a DNA molecule, with the rule that the genes it uses have to be natural 

On Friday, December 13, 2013 2:42:55 PM UTC-8, Mega [Andreas Stuermer] wrote:

I'm sure you could also include a -35 promoter element in that :P then it has four meanings. And a restriction site :D

On Fri, Dec 13, 2013 at 11:24 PM, Koeng <koen...@gmail.com> wrote:

When I read the media release, at first I was like "wow!" But then I actually caught onto what they where saying... and then I just did this - http://i.imgur.com/ZRMeE.gif

But then again, it may be beneficial. If you think about it, going over the top on how important something is when talking to the public may get you more funding, which is likely the purpose of the release. So, I guess, in that sense it is doing its job.

Anyway, if you want something even more amazing, here is a DNA with triple function

AGGAGTGATGTAATG

The beginning is the Shine-Dalgarno sequence, (bold) and the beginning of a new gene in bold as well. Then italicized is 2 stop codons for 2 different CDSs! That means this DNA has information for 2 CDSs AND a ribosomal binding site! "Where's my nobel prize?" :)

(For clarification, this sequence came from phiX174, which is known for overlapping DNA sequences. http://www.ncbi.nlm.nih.gov/nuccore/NC_001422.1 )

-Koeng

On Friday, December 13, 2013 5:18:22 AM UTC-8, Mega [Andreas Stuermer] wrote:

Didn't have time to read it, but may I cite rule16 from http://www.reddit.com/r/science/comments/1sqj63/scientists_discover_second_code_hiding_in_dna/
 

The "double meaning" is simply silly overblown language saying that a sequence of DNA base-pairs might simultaneously be exonal AND regulatory AT THE SAME TIME (in a way that shows a unique pattern of conservation).

Well, even I could have told you that "double function" :P

Here on this list it was mentioned several times that the ribosome binding sites of viral genes are often found in the terminal of the previous coding sites.  Also in the lux genes this occures. Where's our nobel prize? ^^

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