A little late to the party, but the cite would be NEJM from 1996: May 2;334(18):1150-5. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.
Ended 21 months early.
Note the fishing expedition part: relative risk of lung cancer was 1.28 (meaning 28% higher than expected) with a CI of 1.05 to 1.57 and a weak P-value by today's standard. There were no other statistically significant increases in other cancers.
But if you look at 73,135 person-years and chart all their cancers, SOMETHING will show up with a high incidence rate. That's just statistics for you. That's how we end up with studies that show (for example) a certain statin has no benefit in men, but a 10% benefit in (say) Hispanic women. You run enough numbers through the wringer, and you'll find SOME group stands out. Before long, you're finding some obscure cancer drug works astoundingly well in left-handed blind dentists.
On Mon, Feb 10, 2014 at 8:51 AM, Bjonnh <bjonnh-diybio@bjonnh.net> wrote:
>
> On Sun, Feb 09, 2014 at 04:05:56PM +0000, David Murphy wrote:
> > Trials to test if antioxidants were good for
> > your health had to be stopped because so many additional people were dying.
> Really ? Do you have sources about that ?
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