Re: [DIYbio] Re: Ultra-Cheap DNA Printing/Sequencing

On 02/25/2014 10:06 AM, Cathal Garvey wrote:
> The last I saw of DIY-CMOS was an awful handful of gates that did
> something less complex than a 555-timer. I don't see how that could have
> progressed to CPU within a year.

Same here, which is why my first reply to this thread was, "Not in my bag of tricks."

An area of practical evolution in DIY computing, (and sensors also), is organic semiconductors
and room temperature processed inorganics to make fairly large flat circuits. Some
of the semiconductors may work OK on micron scales, but the DIY aspect shoots along
much faster, more effective when aimed at printed circuit scales, such as minimum
feature size of 100 microns.

Back to brainstorming on DNA reading or printing: However you get
electronics interfaced is going to mean going from macro scale with features
of 100 microns to nano scale with features of .1 micron. Some kind
of self assembling nano-pore-or-tube connected in sensor-useful ways
to flags of conducting material along with one nano-pore-or-tube might allow
everything else to follow. So, to my thinking, the problem is crossing scales
mostly, not conceptually how to detect a base pair once they are constrained tightly
so they don't wiggle away while measuring their presence.

What if you could have a bunch of sites that "attract DNA and have some electrodes attached"
located randomly on a plane? So that between them random lengths of DNA might attract to one or more?

Suppose you could sense if a strand were "attracted", and move it, but not "see" anything else?
Then, a way to sense if one strand were attracted" to two stations at once might be found...
by tugging on one end while holding tight to the other and seeing motion stop, or require
higher actuation volts for "tugging a strand" or ??

Anyone else thinking like this?

On 02/25/2014 10:14 AM, SC wrote:> As synthetic DNA isn't that expensive to buy from well established labs, I'm not sure that type
of home business would be able to
> compete effectively in the current marketplace.

Huh? Weren't we discussing how to reduce costs by 100X?

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