Re: [DIYbio] Re: Prospects of anti-aging research

On 04/06/2014 04:08 AM, Mega [Andreas Stuermer] wrote:
> http://www.theguardian.com/science/2012/oct/17/young-blood-reverse-effects-ageing
>
> Fascinating! Injecting young blood into old mice rejuvinated them to some degree. And, what surprised me the most - it was blood plasm (cell free). That means no external stemm cells applied. Just young growth factors that made the old stem cells speed up.
>
There has been a growing amount of work on heterochronic parabiosis in
mice. As I understand it, the current thinking is that the factors
involved are short-lived which is why you actually need the physical
connection to see effects (in absence of a list of those factors to be
delivered as drugs). Another expectation is that achieving the same
result in old humans would greatly raise the risk of cancer - which may
be an acceptable cost during the years ahead in which cancer treatment
is highly effective but researchers have not yet found safe ways to
restore stem cell populations to youthful levels of activity.

http://www.deepdyve.com/lp/wiley/heterochronic-parabiosis-historical-perspective-and-methodological-iQgxME31z2

Some reports on the leading edge of investigations as to the mechanisms
by which heterochronic parabiosis works:

https://www.fightaging.org/archives/2013/09/the-prospects-for-therapies-based-on-heterochronic-plasma-exchange.php

https://www.fightaging.org/archives/2014/03/digging-into-the-details-of-why-a-young-environment-restores-the-activity-of-old-cells.php

https://www.fightaging.org/archives/2013/05/parabiosis-points-to-gdf-11-as-a-means-to-reverse-age-related-cardiac-hypertrophy.php

Reason

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