Re: [DIYbio] interesting crowdfunding projects

Allotopic expression in yeast is indeed a thing, and is still going on
as a tool for certain types of investigation. E.g.:

-
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002876
- http://www.pnas.org/content/107/11/5047.full
- http://www.sciencedirect.com/science/article/pii/S0076687996640361

I'm not so familiar with the early DRACO work, what I see starts with
mammalian cell studies.

Reason

On 10/22/2015 12:19 PM, Dennis Oleksyuk wrote:
> Longevity related research is definitely something very interesting.
>
> But it indeed would require more capable folks. It seems that both of these
> projects involve work with mammalian and eventually human cells, and
> viruses. Which in turn requires skills for working with cell cultures and
> probably BSL-2 facilities. Which out of reach of majority of DYIBio
> communities and individuals.
>
> On the other side, it would be great if these approaches could be
> replicated in yeast or other simple organism. Do you know if any of these
> techniques had early proof-of-concepts in non-mammalian cells?
>
> On Thu, Oct 22, 2015 at 10:24 AM Reason <reason@fightaging.org> wrote:
>
>> The Lifespan.io crowdfunding site has a mitochondrial allotopic
>> expression project currently funded and in the final days that you might
>> find interesting. It seems like something that - aside from the cost of
>> reagents - is within the capabilities of many of the more capable folk
>> in the DIYbio community. The details are certainly worth a read:
>>
>> https://www.lifespan.io/campaigns/sens-mitochondrial-repair-project/
>>
>> The reagent cost issue is kind of an interesting one for DIYbio. The
>> community has made some inroads into address the basic equipment cost,
>> might it also at some point tackle reagents? Or is this something where
>> the path of least resistance is just to wait, expecting the cost
>> implosion for biotechnology to reach these areas as well sooner or later?
>>
>> Another quite fascinating project is the attempt to kick DRACO
>> anti-virus research across the finish line; it is a way to treat near
>> all viruses by killing the cells they replicate in. The inefficiencies
>> in progress are occasionally puzzling; DRACO has solid studies backing
>> it, and a near complete lack of interest from the development community.
>> It is also something where some parts of the work taken in isolation are
>> projects that could in theory be replicated in the DIYbio community, out
>> of interest or curiosity.
>>
>> https://www.indiegogo.com/projects/help-end-viral-diseases-with-dracos#/
>>
>> Lastly I'm raising funds for SENS research again this year: a group of
>> us created a $125,000 matching fund and we will match all donations made
>> to the SENS Research Foundation before the end of the year:
>>
>> https://www.fightaging.org/fund-research/
>>
>> SENS research has had a banner year this year. Oisin Biotechnology has
>> been seed funded to develop a means of senescent cell clearance, another
>> group demonstrated proof of principle senescent cell clearance and
>> corresponding health improvements in mice, Human Rejuvenation
>> Technologies was founded to develop lysosomal aggregate clearing enzymes
>> as a therapy, a method of synthesizing glucosepane was published in
>> Science, Gensight has raised a boatload of money for their allotopic
>> expression work, and in general things are starting to happen as a
>> consequence of past years of philanthropy.
>>
>> Reason
>>
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