[DIYbio] Re: DNA synthesis at 10 cents per letter

Haven't heard of any DIY systems for DNA synthesis yet but I think DNA separation by silica adsorption is part of the method. It might be worth looking into for anyone interested in making such a system. I'm sure both community and industry labs would be very interested in something like that!

On Saturday, November 21, 2015 at 3:27:51 PM UTC-8, technologiclee wrote:
http://www.wired.com/2015/11/making-dna/
"When Twist launches its beta program in 2016, it will offer gene synthesis at 10 cents per letter with a guaranteed turnaround time of 10 days."

"Moreover, the silicon wafer is cleverly optimized for the second step of gene synthesis—the stitching of oligos together—because Twist's engineers figured out how to cut down on moving tiny volumes of liquid. Twist's proprietary machine, a small-car sized system that WIRED wasn't allowed to photograph, deposits one oligo into each of the 100 or so holes inside of a nanowell."

Is there any DIY system capable of this? What would it take to do that? What is the basic mechanism of moving the fluid in this system?

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