What do you think about this? On the one side they have huge genome, what makes possible to insert large sequences. On the other side they replicate outside of nucleus, so they can be used only for something like CRISPR/Cas systems which guidance RNA and proteins can penetrate nucleus. Of course I do not propose to use Variola major virus. I think something like fowlpox or myxoma viruses will be good for this. And currently I have both myxoma (strain V-82) and fowlpox (strain K) viruses, both vaccinal ones.
-- Thanks for advice!
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