The closest I've been able to find (at least as far as I understand what you are asking for) is PSCDB - the Protein Structural Change DataBase, but that one seems heavily focused on structural changes induced by ligand binding, not pH or temperature changes etc.
There are likely also some databases out there with information on what the physiological range is for enzymes or other proteins. But it may not have any info on exactly why they lose their function beyond those parameters - whether it's due to a distinct structural change, or they start to denature, or undergo some other non-structural changes that inhibit their function.
What I am fairly certain you will NOT find, is a database with a large number of proteins documenting in detail how their structure changes with changes with environmental parameters. There just aren't that many proteins that have been documented to switch between distinct structural conformations. And for those proteins we do know about, the characterization of the parameter space will typically be very coarse, e.g. something like "this protein has conformation X at pH 7, but conformation Y at pH 5 in the presence of Ca+".
Patrik
On Thursday, December 7, 2017 at 7:10:01 PM UTC-8, Cory J. Geesaman wrote:
Does anyone know of a set of categorizations for proteins which provide good coverage of all the observed structural conformations?
Examples of what I'm referring to would be the pH, salinity, temperature, and possibly reducing agent concentrations.
The purpose is to try to classify different stable folded proteins for each set of possible changes, so if for instance there's a hard cutoff at a pH of 3 where lower doesn't do anything, or greater than 100C or more than a 90% saturation of salt, or more than a 2% solution with reducing agents (a specific reducing agent or in general,) etc that would be helpful to know. Additionally, if there is somewhat of a gradient that would be helpful (e.g. will a protein fold different at a pH of 6, 7, and 8 - and if so are there known transition points?)
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