Re: [DIYbio] Protein Categorization

On 12/08/2017 08:41 AM, Cory J. Geesaman wrote:
> I don't get why companies designing recombinant proteins specifically would want it,) any idea of the pH scale required to get
> good coverage?

Because once you knew such data points for a range of proteins you would shorten the trial and error of designing
proteins with similar conditions. You'd start to be able to treat proteins like a key to a lock, and know which detent position
on the key you were working with. That would be input to synthesis.

Getting the data on folding needs some kind of observation of folding states though. Visual observing of it probably is not very
easy, so not very useful. Some kind of test, which is why Skyler Gordon was saying get knowledge on microfluidic physics for
corralling molecules, would be a help for categorizing. I can only see it being done by automaton that moves protein molecules
through microscopic chambers of conditions that fold and unfold and also with some detector of folded state. The you could relate
the basic conditions to how the folding happens in presence of other molecules -- the normal way catalyze reactions, but since you
will get observations 2 ways you'll have a rosetta stone to decode more...

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