The effects of rapamycin are... complex. Its primary use (right now) is as an immune system suppressant for transplant patients. Anyone using it for anti-aging needs to be very careful about bacterial infections. It should go without saying that this is not medical advice.
I don't think the mechanism by which rapamycin combats the effects of aging are understood. Of course, aging itself is not well understood.
Here are some papers:
Rapamycin for longevity: opinion article
Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update
Cheers
On Thu, Feb 29, 2024 at 12:24 PM Dakota Hamill <dkotes@gmail.com> wrote:
ooo I love the story of Rapamycin and always start any talks around natural products with it. In 1972 a group from Wyeth Brazil went to Easter Island and took soil samples from the edge of the extinct volcano there. Originally Streptomyces hygroscopicus had a bio-active being pursued for anti-fungal properties. Turns out it was an amazing immune suppressant (I do not know how this was tested). Rapamycin, named after the native people's name for the island, Rapa Nui, is still used today to coat heart stents and after organ transplantation.The molecule has 15 chiral centers, and if you do 2^15 there are 32,768 unique isomers. And a little microbe, eating decaying organic matter, with some oxygen, beautifully synthesizes an amazingly active molecule which is a multi billion dollar life saving medicine.I've never heard about its anti aging uses, would like to hear more.--On Thu, Feb 29, 2024 at 12:49 PM Daniel C. <dcrookston@gmail.com> wrote:I am very interested in this list not being spammed with advertisements for quackery.I especially like how you don't talk about rapamycin, the most effective anti-aging drug currently available, which is a generic medication and therefore not profitable.----Members,
My name's Johnny Adams.
I recently moved to Florida to be active in two initiatives that I believe have the greatest potential for biological age management and reversal:
- Yamanaka/OSK gene therapy to reset the epigenome. A therapy is a few years away.
- A plasma project involving therapeutic plasma replacement, infusion and exchange
It will initially be available in Florida, then in other parts of the country.
More information:
https://www.aginginterventionfoundation.org/JohnnyAdamsPlasmaProjectSummary.pdf
Please contact me if you have any interest.
Johnny
1-949-922-9786 cell
JAdams@AgingInterventionFoundation.org
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