Re: back of the napkin metabolic engineering

I know that Serratia marcescens also produces prodigiosin. I haven't
looked that much into it, but I believe that S. marcescens is better
characterized than P. mirabilis. If my memory serves, all but the last
few steps in the biosynthetic pathway of prodigiosin remain a mystery.
I found an article that outlines some of the genes (regulatory and
otherwise) involved in prodigiosin synthesis.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067589/?tool=pmcentrez
I would look a bit further, but my brain is fried from a long day. I
thought this might be a place to begin the search.

On Jan 18, 9:28 pm, Mackenzie Cowell <m...@diybio.org> wrote:
> Hey folks,
>
> Just read an interesting article on Quora, "What are some of the most
> interesting bacteria?<http://www.quora.com/What-are-some-of-the-most-interesting-bacteria/>"
> that was shared w/ the list a while back.  My favorite answer (besides the
> one about Mixotricha), is Maria Suyay's
> post<http://www.quora.com/What-are-some-of-the-most-interesting-bacteria/a...>about
> Proteus mirabilis.  She notes that the bacteria synthesize an
> interesting red pigment, prodigiosin.  I'm always on the lookout for cool
> bacterially-produced pigments, and this is a new one for me.
>
> So this seems like a good opportunity to learn a little bit about basic
> metabolic engineering / syn bio: What databases might one check to figure
> out what genes P. mirabilis uses to synthesize prodigiosin?  How could one
> subsequently determine what subset of this pathway would be needed in E.
> coli for the synthesis?
>
> Cheers
> Mac
>
> --
> +1.231.313.9062 / m...@diybio.org / @100ideas

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