This is one question I might be able to pitch in a bit.
I started with a Google search of Proteus mirabilis, and I specifically queried for it's genome sequence. I got back these results:
Apparently, there's a plasmid and a genome sequence available:
- http://www.ebi.ac.uk/Tools/dbfetch/dbfetch?db=embl&id=AM942760&style=raw (this is the genome)
- Plasmid seems to be not accessible.
After a few more steps, it seems like there's a really good paper that talked a bit about prodigiosin synthesis by homologous enzymes in a different organism (the Pig and Red genes).
I've gotta write some other emails now, but I'm going to follow this thread more closely!
Cheers,
Eric
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On Wed, Jan 18, 2012 at 9:28 PM, Mackenzie Cowell <mac@diybio.org> wrote:
Hey folks,Just read an interesting article on Quora, "What are some of the most interesting bacteria?" that was shared w/ the list a while back. My favorite answer (besides the one about Mixotricha), is Maria Suyay's post about Proteus mirabilis. She notes that the bacteria synthesize an interesting red pigment, prodigiosin. I'm always on the lookout for cool bacterially-produced pigments, and this is a new one for me.So this seems like a good opportunity to learn a little bit about basic metabolic engineering / syn bio: What databases might one check to figure out what genes P. mirabilis uses to synthesize prodigiosin? How could one subsequently determine what subset of this pathway would be needed in E. coli for the synthesis?CheersMac--
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